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Cell cover boundaries triangles
Cell cover boundaries loops
  • March 2015

Breaking Chromatin Boundaries

These cover candidates for CELL illustrate the research of the Mundlos lab at Max Planck Institute for Molecular Genetics, Berlin. The group studies mammalian genomes which are organized into large-scale topologically associated domains (TADs) that represent large regulatory units. Their research showed that disruption of TADs by deletions, inversions or duplications can cause rewiring of long-range regulatory architecture and result in pathogenic phenotypes such as distinct human limb malformations.

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