These cover candidates for CELL illustrate the research of the Mundlos lab at Max Planck Institute for Molecular Genetics, Berlin. The group studies mammalian genomes which are organized into large-scale topologically associated domains (TADs) that represent large regulatory units. Their research showed that disruption of TADs by deletions, inversions or duplications can cause rewiring of long-range regulatory architecture and result in pathogenic phenotypes such as distinct human limb malformations.
